The Santa Ysabel Stakes is an American Thoroughbred horse race run annually during the second week of January at Santa Anita Park in Arcadia, California. A Grade III event, the race is open to fillies, age three, willing to race one and one-sixteenths miles (8.5 furlongs) on the dirt. Inaugurated in 1968, the Santa Ysabel Stakes was contested at 7 furlongs in 1970. It was run in two divisions in 1968, 1970, 1972, and 1979.